Sperm dysfunction and ciliopathy
نویسندگان
چکیده
منابع مشابه
Sperm abnormalities: Adverse effects of thyroid dysfunction
Introduction: Despite the importance of thyroid hormones in reproduction, there are only a few studies that focus on male infertility. The objective of this study was to evaluate semen parameters in patients with hypothyroidism or hyperthyroidism. Materials and methods: Totally, 28 patients with thyroid disorders were evaluated for the semen parameters. Serum TSH and T4 concentrations were mea...
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Oxidative stress has been identified as a crucial factor leading to male infertility largely due to peroxidativedamage to the sperm cell membrane. Cadmium (Cd) is a widespread environmental pollutant and oneof the well-known reproductive toxicants. Because of its long biological half-life (10–30 years), Cdaccumulates in the biological systems. The present study was designed to assess the concen...
متن کاملCan mitochondrial DNA mutations cause sperm dysfunction?
Very low levels of somatic mitochondrial (mt)DNA deletions have been identified in the semen of infertile men. It has been suggested that these mutations cause infertility through an effect on sperm motility, but there has been no direct evidence to show that mutant mtDNA can affect sperm function. We have carried out semen analysis on a male harbouring the A3243G mtDNA mutation and show that h...
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The spindle assembly checkpoint (SAC) is a surveillance mechanism of faithful chromosome segregation during mitosis. Budding uninhibited by benzimidazole-related-1 (BubR1) plays a central role in the SAC through inhibition of anaphase promoting complex/cyclosome (APC/C) activity until all chromosomes have established proper attachment to the mitotic spindle. Loss-of-function mutations in the BU...
متن کاملThe global health problems of infertility and sperm dysfunction
The global health problems of infertility and sperm dysfunction In a world in which population growth and its subsequent control seem to be critical problems, it is counterintuitive to think that one in six couples are subfertile (still trying for a child after over 1 year of unprotected intercourse). In fact, approximately 80 million couples throughout the world are subfertile [1]. What is per...
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ژورنال
عنوان ژورنال: Reproductive Medicine and Biology
سال: 2015
ISSN: 1445-5781
DOI: 10.1007/s12522-015-0225-5